Regulation of Notch1 and Foxp1 by MiR-34a in Psoriasis Vulgaris
نویسندگان
چکیده
This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in development psoriasis vulgaris. RT-PCR was used compare levels skin lesions 20 patients with vulgaris normal tissues. Immunohistochemistry detect expression 51 vulgaris, which were further compared that 29 control In addition, HaCaT cells, we mimics inhibitors overexpress inhibit miR-34a, respectively, detected mRNA protein Notch1, Foxp1. The level significantly higher than tissues (t=2.192, P<0.05). positive rate 76.47 %, (13.79 %) (t=29.215, P<0.01). FOXP1 group 92.16 also (65.52 (t=9.087, overexpression promoted However, inhibition reduced levels. miR- 34a highly expressed may participate regulating
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ژورنال
عنوان ژورنال: International Journal of Morphology
سال: 2022
ISSN: ['0717-9502', '0717-9367']
DOI: https://doi.org/10.4067/s0717-95022022000300735